Osterly Market SAM-e 400 mg

400 mg SAM-e. Enteric coated.

Four hundred milligrams of SAM-e in an enteric-coated tablet — a coating this compound genuinely needs and often does not get.

What it's for

SAM-e is a molecule your body makes from methionine and ATP, involved in methylation reactions throughout the body. It is taken for joint comfort and for mood, and it has more human trial data behind it than most ingredients in this category.

How to take it

• One tablet daily on an empty stomach, ideally in the morning
• Food reduces absorption, so time it away from meals
• Joint effects generally take three to four weeks; mood effects have shown faster in trials
• This one has real interactions. Do not combine it with antidepressants, and speak to a doctor first if you have bipolar disorder — SAM-e has triggered mania in some cases

On the label

• 400 mg per tablet
• Enteric coated
• 60 tablets
• Single ingredient

What this is not

• Not an antidepressant
• Not to be combined with SSRIs without medical advice
• Not effective uncoated, which is why the coating is on the label

The straight answer

Uncoated SAM-e is largely destroyed by stomach acid. If a SAM-e product does not say 'enteric coated' anywhere, that omission is the most informative thing on the bottle.

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Talk to your doctor before starting any supplement, especially if you are pregnant, nursing, or taking prescription medication.